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癌症是一种非常狡猾、适应性强的疾病。从事医学研究和教育工作的保拉•哈蒙德认为，要打败癌症，我们需要全新的、强有力的进攻方式。哈蒙德同她麻省理工学院的同事一起，制造了一种纳米粒子，尺寸只有头发的百分之一，能对付最致命且具有抗药性的癌症。让我们进一步了解这种分子武器，同哈蒙德并肩作战，共同抗击我们共同的敌人——癌症。
n. 果心，核心，要点
vt. 挖去果核
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- The siRNA is deployed first. It acts for hours, giving enough time to silence and block those survival genes.
- siRNA首先开始行动。它需要几个小时，来让（癌细胞的）生存基因失效。
- We have now disabled those genetic superpowers.
- 我们去除了（癌细胞的）基因超能力。
- What remains is a cancer cell with no special defenses.
- 只剩下没有防御的癌细胞。
- Then, the chemotherapy drug comes out of the core and destroys the tumor cell cleanly and efficiently.
- 之后化学药剂从内核中释放出来干净利落地杀死肿瘤细胞。
- With sufficient gene blockers, we can address many different kinds of mutations,
- 只要有足够多的基因拦截者，我们就能对付各种变异（的癌细胞），
- allowing the chance to sweep out tumors, without leaving behind any bad guys.
- 有机会消灭肿瘤，不留落网之鱼。
- So, how does our strategy work?
- 那么，我们的方法到底有没有效呢？
- We've tested these nanostructure particles in animals using a highly aggressive form of triple-negative breast cancer.
- 我们进行了动物实验，使用的是一种非常厉害的癌症，三阴性乳腺癌。
- This triple-negative breast cancer exhibits the gene that spits out cancer drug as soon as it is delivered.
- 它的基因非常厉害，能迅速将抗癌药排出。
- Usually, doxorubicin -- let's call it "dox"
- 通常，我们会使用阿霉素这种抗癌药，
- is the cancer drug that is the first line of treatment for breast cancer.
- 它是治疗乳腺癌的首选手段。
- So, we first treated our animals with a dox core, dox only.
- 第一次，我们只用阿霉素来对动物进行治疗。
- The tumor slowed their rate of growth, but they still grew rapidly, doubling in size over a period of two weeks.
- 肿瘤的增长率有所减缓，但还是增长很快，两周之内就增长了一倍。
- Then, we tried our combination superweapon.
- 接下来，我们的超级武器上场了。
- A nanolayer particle with siRNA against the chemo pump, plus, we have the dox in the core.
- 外层是siRNA，保护自身不被拦截，内核部分是阿霉素。
- And look -- we found that not only did the tumors stop growing,
- 结果我们发现，肿瘤不但没有增长，
- they actually decreased in size and were eliminated in some cases. The tumors were actually regressing.
- 而且变小了，在某些样本上甚至完全消失。肿瘤被击退了。
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| 重点单词 | 查看全部解释 | |||
| core | [kɔ:] | |||
| sufficient | [sə'fiʃənt] | 联想记忆 | ||
| genetic | [dʒi'netik] | 联想记忆 | ||
| silence | ['sailəns] | |||
| pump | [pʌmp] | |||
| address | [ə'dres] | |||
| strategy | ['strætidʒi] | |||
| combination | [.kɔmbi'neiʃən] | 联想记忆 | ||
| cell | [sel] | |||
| aggressive | [ə'gresiv] | 联想记忆 |
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