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- So, here's our strategy. First, we'll dose the cancer cell with siRNA, the gene blocker,
- 因此,我们的策略如下。首先,我们将siRNA--基因拦截者,用在癌细胞身上,
- and silence those survival genes, and then we'll whop it with a chemo drug.
- 让(癌细胞的)生存基因失效,然后我们再用化学药品来对付癌细胞。
- But how do we carry that out?
- 但如何实现呢?
- Using molecular engineering, we can actually design a superweapon that can travel through the bloodstream.
- 答案是分子工程技术,我们可以设计一种超级武器,能在血液循环中存活下来。
- It has to be tiny enough to get through the bloodstream, it's got to be small enough to penetrate the tumor tissue,
- 它必须足够小,才可以进入血液循环,它必须足够小,才可以穿过肿瘤组织,
- and it's got to be tiny enough to be taken up inside the cancer cell.
- 它必须足够小,才可以进入癌细胞内部,
- To do this job well, it has to be about one one-hundredth the size of a human hair.
- 要做到这一点,它的尺寸必须小到头发的百分之一。
- Let's take a closer look at how we can build this nanoparticle.
- 来仔细看一下我们是如何制造这种纳米粒子的。
- First, let's start with the nanoparticle core.
- 首先,我们要制造纳米核。
- It's a tiny capsule that contains the chemotherapy drug.
- 那是一颗小胶囊,内含化学药剂。
- This is the poison that will actually end the tumor cell's life.
- 对肿瘤细胞而言是致命毒药。
- Around this core, we'll wrap a very thin, nanometers-thin blanket of siRNA. This is our gene blocker.
- 在内核周围,我们包上一层很厚的--当然也就几纳米厚的siRNA。这是我们的基因拦截者。
- Because siRNA is strongly negatively charged,
- 因为siRNA带负电,
- we can protect it with a nice, protective layer of positively charged polymer.
- 我们用一层坚固的,带正电的聚合物来保护它。
- The two oppositely charged molecules stick together through charge attraction,
- 这两种带有不同电荷的分子相互吸引,
- and that provides us with a protective layer that prevents the siRNA from degrading in the bloodstream. We're almost done.
- 形成一层保护膜,防止siRNA在血液中被降解。别着急,我快说完了。
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癌症是一种非常狡猾、适应性强的疾病。从事医学研究和教育工作的保拉•哈蒙德认为,要打败癌症,我们需要全新的、强有力的进攻方式。哈蒙德同她麻省理工学院的同事一起,制造了一种纳米粒子,尺寸只有头发的百分之一,能对付最致命且具有抗药性的癌症。让我们进一步了解这种分子武器,同哈蒙德并肩作战,共同抗击我们共同的敌人——癌症。
来源:可可英语 http://www.kekenet.com/Article/201902/579168.shtml
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strategy
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['strætidʒi]
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survival
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[sə'vaivəl]
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联想记忆
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单词survival 联想记忆: sur后+viv活+al表名词,“人,物,状态”→事故后活下来→幸存→生存,幸存
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capsule
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['kæpsju:l]
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联想记忆
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单词capsule 联想记忆: cap头,sule拼:酥了。吃完胶囊头就不痛了,因为没有感觉。
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protect
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[prə'tekt]
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联想记忆
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单词protect 联想记忆: pro在前面+tect盖上→在前面盖上→保护;防止
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penetrate
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['penitreit]
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联想记忆
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单词penetrate 联想记忆: pen笔,etr=enter进入,ate吃-把笔吃了-刺穿
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dose
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[dəus]
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core
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[kɔ:]
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layer
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['leiə]
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联想记忆
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单词layer 联想记忆: 不认识的同学回家学学Photoshop就ok了
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blanket
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['blæŋkit]
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tissue
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['tiʃu:]
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