Children diagnosed with soft tissue sarcoma, neuroblastoma, non Hodgkin's lymphoma, brain tumors, male survivors of leukemia, non amputated females
被诊断有软组织肉瘤、神经母细胞瘤、 非霍奇金淋巴瘤、脑瘤的孩子 白血病的幸存男士,患有骨癌
with bone cancer, Wilms tumors and survivors of Hodgkin's disease are more likely to be underweight later in life whereas children diagnosed with acute
because they cause structural and functional injuries to the gastro intestinal tract preventing an adequate oral intake even later in life.
因为他们会造成胃肠道的结构和功能损伤 以致在后来的生活中 口服食物得不到充足的营养
This chart gives an overall comparison of the short term and long term consequences of malnutrition during childhood cancer. The ones that we have already
discussed are bolded and some other important consequences include the wasting of muscle and fat mass, drug dose alterations, retardation of
另外一些重要的结果包括 消耗掉肌肉和脂肪量 药物用量改变、阻滞了骨骼肌的发展
skeletal muscles and even an increased risk for secondary cancers. So clearly avoiding malnutrition during treatment is extremely important. We will now
甚至增加了二次癌症的危险 显而易见,在治疗期间避免营养不良 是极其重要的
turn our focus to the nutritional interventions that can be used to avoid malnutrition. We will now turn our attentions to the nutritional interventions
我们将把注意力转移到 可以避免营养不良的 营养干预上 这种营养干预最常用在
most commonly used in a clinical setting. There are 3 main feeding practices used in healthcare facilities, supplemental or oral feeding, enteral or
临床环境中 在医疗保健设施中有三种主要的喂养方式 补授法或经口喂养,肠内管饲和
tube feeding and parenteral or IV feeding. Oral feeding is the best method of support for patients with a low nutritional risk.
肠内或静脉注射 对营养缺乏不严重的病人, 口服喂养是最好的方式
Some children will still need dietary supplements due to an increase in nutrient needs such as calcium. Ideally there should be flexibility in menu choice and meal times.
Studies have shown that a more flexible meal service can lead to a significant increase in children's food, protein and energy intakes.
研究表明,相比而言灵活的进餐服务对 孩子们的食物、蛋白质和能量吸收 有重要的作用
Enteral nutrition is a practical method when oral intake and the weight of a child continue to decrease. Enteral nutrition works well if the child's gut is
儿童在口服营养,体重仍然持续下降时 肠内营养是个很实用的方式 如果儿童的肠道功能如果仍然很好的话
still functioning properly. Enteral feeding also has the advantage of preserving the integrity of the intestinal mucousa. Parenteral nutrition is best used
Research has indicated that when normal oral intake is not possible enteral nutrition has more physiological benefits compared to parenteral nutrition
研究表明,在不能正常口服时,肠内营养 在生理上比肠胃外营养更具有优势 这优势包括保持小肠绒毛
including the maintenance of the heightened activity of intestinal villi and brush border enzymes, better preservation of specific gut nutrients such as
及小肠刷状缘酶活性的提高 能更好地保护 小肠营养内特殊物质
glutamine and short chain fatty acids and an upholding of the mucosal membrane surrounding the intestine. Enteral nutrition is also associated with fewer
比如像谷酰酶、短链脂肪酸 和支撑小肠周围黏膜的薄膜 肠内营养也和不少的传染病
infections and complications however many studies are continuing to show that parenteral nutrition is more successful at preventing and correcting malnutrition.